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US 11,952,351 B2Granted
Lipid particle, composition comprising lipid particle, and method for delivering activators to cell
AssigneeKabushiki Kaisha Toshiba
InventorsMitsuko Ishihara, Eiichi Akahoshi, Katsuyuki Naito, Emi Nozaki, Saeko Saruwatari
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Abstract
The present embodiment provides a compound represented by the formula (1): Q-CHR2 (1) (Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and R is an aliphatic group containing a biodegradable group). From the compound in combination with other lipids such as a lipid capable of reducing aggregation, lipid particles can be formed. Further, the compound can be used for a pharmaceutical composition to deliver an activator into cells.
Claims27
Lipid particles comprising a lipid compound represented by the formula (1):
- Q-CHR2 (1)
- wherein
- Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and
- each R is independently an aliphatic group of C12 to C24, and is represented by the following formula (1-R):
- -LR1-C(═O)—O-LR2 (1-R)
- wherein
- LR1 and LR2 are alkylene and alkenyl, respectively;
- wherein the lipid particles contain
- 25 to 75 mol % of said lipid compound represented by the formula (1);
- and
- 1 to 10 mol % of a lipid capable of reducing aggregation,
- based on the total number of moles of the lipids used for the lipid particles, respectively.
9 more elements
Dependencies are inferred from the claim text.