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US 11,952,350 B2Granted
Process for the preparation of fungicidally active strobilurin compounds and intermediates thereof
AssigneeUpl Ltd
InventorsPrashant Vasant Kini, Santosh Ganpat Shelke
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Abstract
The present invention relates to a process for the preparation of strobilurin of compounds of Formula (I) of and its intermediates using 1,5,7-triazabicyclo[4.4.0]dec-5-ene or salts thereof, or derivatives thereof as a catalyst. The present invention provides the compounds of formula (I) in high yield and high purity.
Claims19
A process for preparation of a compound of Formula (I) comprising:
- reacting a compound of Formula (II) with a compound of Formula (III) in the presence of a 1,5,7-triazabicyclo[4.4.0]dec-5-ene or a salt thereof as a catalyst;
- wherein,
- R is selected from halogen and nitrile;
- X1 is selected from hydrogen and fluorine;
- X2 is chlorine;
- and
- Q is selected from methyl (E)-2-(3-methoxy) acrylate, methyl 2-(3,3-dimethoxy) propanoate, and 5,6-dihydro-1,4,2-dioxazin-3-yl-N-methoxymethanimine.
4 more elements
A process for preparation of a compound of Formula (II) comprising:
- reacting a compound of Formula (V) with a compound of Formula (IV) in the presence of a 1,5,7-triazabicyclo[4.4.0]dec-5-ene or a salt thereof as a catalyst;
- wherein,
- X1, X2 and X3 are independently selected from hydrogen, chlorine and fluorine;
- M is selected from hydrogen and an alkali metal;
- and
- Q is selected from methyl (E)-2-(3-methoxy) acrylate, methyl 2-(3,3-dimethoxy) propanoate, and 5,6-dihydro-1,4,2-dioxazin-3-yl-N-methoxymethanimine.
3 more elements
A process for preparation of a compound of Formula (I) comprising:
- reacting a compound of Formula (VI) with a compound of Formula (IV) in the presence of a 1,5,7-triazabicyclo[4.4.0]dec-5-ene or a salt thereof as a catalyst
- wherein R is selected from halogen and nitrile;
- X1 is selected from hydrogen and fluorine, X2 is selected from chlorine and fluorine;
- Q is selected from methyl (E)-2-(3-methoxy) acrylate, methyl 2-(3,3-dimethoxy) propanoate, and 5,6-dihydro-1,4,2-dioxazin-3-yl-N-methoxymethanimine;
- and M is selected from hydrogen and sodium.
2 more elements
Dependencies are inferred from the claim text.