Modulators of mas-related G-protein receptor X2 and related products and methods

A compound having structure (Ib):

• or a pharmaceutically acceptable salt, stereoisomer, hydrate, solvate or isotope thereof, wherein:
• R1 is aryl or heteroaryl, wherein R1 is optionally substituted with one or more Rq1;
• each Rq1 is independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, —OR, —O(CH2)nR, haloalkoxy, —C(O)OR, —C(O)R, —OC(O)R, halo, haloalkyl, —CN, —N(R)2, —N(R)C(═NH)N(R)2, —N(R)C(O)R, —N(R)S(O)2R, S(O)2R, —C(H)Q′R, or —(CH2)nQ′ where Q′ is selected from C1-6 alkyl, aryl, cycloalkyl, heterocyclyl, OR′, —C(O)OR′, —OC(O)R′, haloalkyl, —CN, —N(R′)2, —N(R′)C(O)R′, and —N(R′)S(O)2R′;
• each R is independently H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —C(O)NHR′, amino, —(CH2)nR′, halo, aryl, cycloalkyl, heteroaryl or heterocyclyl, or two R groups taken together with the atom to which they are attached form a carbocyle or heterocycle;
• each R′ is independently H, C1-6 alkyl, haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, or heterocyclyl;
• Rd is —CN;
• Rw is H;
• Rz is H;
• R2 is H;
• and
• each R3 is H.