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US 11,952,334 B2Granted
Cocrystals of ubiquinone and compositions comprising them
AssigneeCenter for Intelligent Research In Crystal Engineering, S.L.
InventorsLidia Bofill Herrera, Dafne De Sande Lopez, Rafel Prohens López, Rafael Barbas Cañero
Life of this patent
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Abstract
The present invention relates to a cocrystal of ubiquinone and a hydrogen bond donor coformer, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The invention also relates to compositions comprising the cocrystal.
Claims7
A cocrystal of ubiquinone and a phenolic compound, wherein the phenolic compound is:
- 1) 4-hydroxybenzoic acid, and which is characterized by having an X-ray powder diffractogram that comprises characteristic peaks at 1.4 and 2.8±0.3 degrees 2 theta with Cu—Kα radiation, λ=1.5418 Å;
- 2) hydroquinone, and which is characterized by having an X-ray powder diffractogram that comprises characteristic peaks at 1.5 and 3.0±0.3 degrees 2 theta with Cu—Kα radiation, λ=1.5418 Å;
- 3) hydroquinone and which is in the form of a benzyl alcohol solvate, characterized by having an X-ray powder diffractogram that comprises characteristic peaks at 1.4, 2.9±0.3 degrees 2 theta with Cu—Kα radiation, λ=1.5418 Å;
- 4) orcinol, and which is characterized by having an X-ray powder diffractogram that comprises characteristic peaks at 1.5, 3.1±0.3 degrees 2 theta with Cu—Kα radiation, λ=1.5418 Å;
- 5) Orcinol, and which is in the form of a benzyl alcohol solvate, characterized by having an X-ray powder diffractogram that comprises characteristic peaks at 12.9, 13.6±0.3 degrees 2 theta with Cu—Kα radiation, λ=1.5418 Å;
- 6) phloroglucinol, and which is characterized by having an X-ray powder diffractogram that comprises characteristic peaks at 1.5, 3.0±0.3 degrees 2 theta with Cu—Kα radiation, λ=1.5418 Å;
- 7) resorcinol, and which is characterized by having an X-ray powder diffractogram that comprises characteristic peaks at 1.5, 3.0±0.3 degrees 2 theta with Cu—Kα radiation, λ=1.5418 Å;
- or
- 8) 2,4-dihydroxybenzoic acid, and which is characterized by having an X-ray powder diffractogram that comprises characteristic peaks at approximately 1.4 and 18.7±0.3 degrees 2 theta with Cu—Kα radiation, λ=1.5418 Å.
6 more elements
Dependencies are inferred from the claim text.