Product 1,3-butylene glycol
AssigneeKH Neochem Co., Ltd.
InventorsHirotaka Tanaka, Takashi Hakumura, Jun Kanada
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Abstract
A product 1,3-butylene glycol, wherein, in an HPLC analysis under specific conditions after specific sample preparation, when a relative retention time of 2,4-dinitrophenylhydrazine is regarded as 1.0, a sum area value of absorbance peaks that appear within a relative retention time range of 4.4 to 12.0 is 1000 or less, and wherein a dinitrophenylhydrazine derivative of a carbonyl compound having 4 to 6 carbon atoms is contained as a component that corresponds to the peaks that appear within the relative retention time range of 4.4 to 12.0.
Claims3
A product 1,3-butylene glycol, wherein, in an HPLC analysis under the following conditions after the following sample preparation, when a relative retention time of 2,4-dinitrophenylhydrazine is regarded as 1.0, a sum area value of absorbance peaks that appear within a relative retention time range of 4.4 to 12.0 is 1000 or less, and wherein
- a dinitrophenylhydrazine derivative of a carbonyl compound having 4 to 6 carbon atoms is contained as a component that corresponds to the peaks that appear within the relative retention time range of 4.4 to 12.0,
- wherein the sample preparation is as follows:
- 1000 μL of a solution of 2,4-dinitrophenylhydrazine which is extracted by adding 5 mL of acetonitrile to a 2,4-dinitrophenylhydrazine cartridge and 100 μL of 0.2 mol/L hydrochloric acid are added to 0.05 g of the product 1,3-butylene glycol and reacted at 45° C. for two hours, and
- wherein the conditions of HPLC analysis are as follows:
- measurement sample:
- a reaction liquid obtained by the sample preparation is diluted to 2 mL with a mobile phase that is used in HPLC, and the diluted liquid is used as a measurement sample,
- detector:
- UV-Vis detector,
- detection wavelength:
- 369 nm,
- analysis column:
- a column in which palmitamidopropyl group-modified silica gel (particle diameter:
- 5 μm, inner diameter×length=4.6 mm×25 cm, pore size:
- 100 Å, surface coating level:
- 2.7 μmol/m2, surface area:
- 450 m2/g, metal impurity:
- less than 5 ppm, carbon content:
- 19.5%) is used as a stationary phase,
- analysis condition:
- column temperature of 40° C.,
- mobile phase:
- acetonitrile/distilled water=50/50 (volume ratio),
- mobile phase flow rate:
- 0.4 mL/min.,
- sample injection amount:
- 20 μL.
Dependencies are inferred from the claim text.