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US 11,951,307 B2Granted
Targeted remote electrostimulation by interference of bipolar nanosecond pulses
AssigneeOld Dominion University Research Foundation
InventorsAndrei G. Pakhomov, Olga N. Pakhomova, Shu Xiao
Life of this patent
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Abstract
Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
Claims20
A system comprising:
- an array of electrodes comprising a first pair of electrodes and a second pair of electrodes;
- a pulse generator configured to generate a first set of bipolar pulses to be delivered from the first pair of electrodes and a second set of bipolar pulses from the second pair of electrodes, so that the first set of pulses superimposes with the second set of pulses to create a monopolar electric pulse at a location remote from the array of electrodes;
- and
- at least one power supply operably connected to the pulse generator.
1 more element
A system comprising:
- an array of electrodes comprising a first at least two electrodes and a second at least two electrodes;
- one or more pulse generators configured to generate a first set of biologically ineffective bipolar electric pulses to be delivered from the first at least two electrodes and a second set of biologically ineffective bipolar electric pulses to be delivered from the second at least two electrodes, so that the first set of biologically ineffective bipolar pulses and the second set of biologically ineffective bipolar electric pulses superimpose to create one or more biologically effective monopolar electrical pulses at a location remote from the array of electrodes;
- and
- at least one power supply operably connected to the one or more pulse generators.
1 more element
A system comprising:
- an array of electrodes comprising a first at least two electrodes and a second at least two electrodes;
- a pulse generator configured to generate a first set of pulses to be delivered from the first at least two electrodes and a second set of pulses from the second at least two electrodes, so that the first set of pulses superimposes with the second set of pulses to create a monopolar electric pulse at a location remote from the array of electrodes;
- and
- at least one power supply operably connected to the pulse generator,
- wherein a number of phases of each pulse of the first set of pulses differs from a number of phases of each pulse of the second set of pulses by one phase.
2 more elements
Dependencies are inferred from the claim text.