Hemostatic composition and preparation method therefor
AssigneeZhejiang University
InventorsJie Fan, Lisha Yu, Liping Xiao, Hao Chen, Xiaoqiang Shang
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AssigneeZhejiang University
InventorsJie Fan, Lisha Yu, Liping Xiao, Hao Chen, Xiaoqiang Shang
Estimating the term…
Provided is a hemostatic composition comprising trypsin and zeolite, wherein pore channels of the zeolite are micropores, the zeolite contains divalent metal cations, and the mass ratio of the trypsin to the zeolite is 1:200-4:10. In the present invention, the trypsin specifically binds to the zeolite, allowing the trypsin to maintain a certain conformation on the surface of the zeolite and to obtain a higher procoagulant activity, thereby obtaining a hemostatic composition with an excellent blood coagulation effect. The hemostatic composition of the present invention has the advantages of a simple preparation method, low cost and convenient use, and can be widely used in hemostasis during trauma and operations, especially in emergent hemostasis in hemophilia patients.
A hemostatic composition, comprising zeolite and trypsin, wherein pores of the zeolite have a pore diameter of less than 2 nm;
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