Compounds and compositions for use
AssigneeDr Weller Limited
InventorMike Finnen
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compounds and compositions which may be used to augment, supplement and/or replace the products of certain UV sensitive/dependent processes. In particular, the disclosure provides sunscreen compositions which avoid problems associated with prior art sunscreen compositions which inhibit the natural progression of certain in vivo sunlight/UV dependent processes including processes which result in Nitric Oxide/Vitamin D production in the skin.
Claims14
A method of treating diseases associated with reduced, impaired or inhibited nitric oxide (NO) and/or vitamin D production, said method comprising administering to a subject in need thereof a composition comprising:
- (i) a thiol compound selected from the group consisting of:
- glutathione, cysteine, homocysteine, cysteamine and thiolactate, and/or a disulfide selected from the group consisting of:
- dithioglycolate;
- lipoic acid (oxidised) and cystine;
- and
- (ii) a NO-precursor compound selected from the group consisting of:
- nitrite-containing compounds;
- nitrate-containing compounds;
- and nitro-containing organic compounds.
A method of augmenting or stimulating nitric oxide (NO) production in a subject in need thereof, said subject wearing or using a sunscreen composition, said method comprising using, applying or administering a sunscreen composition comprising:
- (i) a thiol compound selected from the group consisting of:
- glutathione, cysteine, homocysteine, cysteamine and thiolactate, and/or a disulfide selected from the group consisting of:
- dithioglycolate;
- lipoic acid (oxidised) and cystine;
- and
- (ii) a NO-precursor compound selected from the group consisting of:
- nitrite-containing compounds;
- nitrate-containing compounds;
- and nitro-containing organic compounds.
A method of providing a sunscreen composition which:
- (i) does not substantially inhibit NO and/or vitamin D production in a subject in need thereof;
- and/or
- (ii) which facilitates, enhances, induces and/or stimulates a level of vitamin D and/or NO production in a subject in need thereof;
- said method comprising supplementing a sunscreen composition with:
- (i) (a) a thiol compound selected from the group consisting of:
- glutathione, cysteine, homocysteine, cysteamine and thiolactate, and/or a disulfide selected from the group consisting of:
- dithioglycolate;
- lipoic acid (oxidised) and cystine;
- and
- (b) a NO-precursor compound selected from the group consisting of:
- nitrite-containing compounds;
- nitrate-containing compounds;
- and nitro-containing organic compounds;
- and optionally
- (ii) 7-dehydrocholesterol.
Dependencies are inferred from the claim text.