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US 11,951,187 B2Granted
NIR-II imaging probe and methods of using the NIR-II imaging probe for dynamic in vivo tracking
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsZhen Cheng, Hao Chen
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Abstract
The disclosure provides NIR-II imaging probes and methods of using the NIR-II imaging probes for dynamic in vivo tracking of cells, such as stem cells, or other substances. NIR-II imaging probes can include a biocompatible NIR-II dye molecule coupled to an organic, biocompatible protein carrier complex, including a carrier protein coupled to a cell-penetrating peptide.
Claims15
An NIR-II optical imaging probe comprising:
- a biocompatible NIR-II dye molecule coupled to an organic, biocompatible protein carrier complex, the protein carrier complex comprising a carrier protein coupled to a cell-penetrating peptide (CPP),
- wherein the probe emits detectable NIR-II fluorescence and wherein the molar ratio of the NIR-II dye molecule to carrier protein to CPP is from about 0.5-1.5 NIR-II dye molecule to 0.5-1.5 carrier protein to 0.5-1.5 CPP.
Dependencies are inferred from the claim text.