RNA constructs and uses thereof
AssigneeBioNTech SE
InventorsUgur Sahin, Gábor Boros, Azita Josefine Mahiny, Jonas Reinholz, Katalin Karikó
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Abstract
Disclosed herein are RNA polynucleotides comprising a 5′ Cap, a 5′ UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.
Claims49
A composition or medical preparation comprising an RNA polynucleotide comprising a sequence encoding a payload, wherein:
- the RNA polynucleotide optionally comprises a modified uridine in place of one or more uridines;
- and
- the 5′ terminus of the RNA polynucleotide comprises m7(3′OMeG)(5′)ppp(5′)(2′OMeA1)pG2pA3pA4pN5, wherein N5 is uridine or a modified uridine.
A pharmaceutical composition comprising an RNA polynucleotide formulated as a particle, wherein the RNA polynucleotide comprises a sequence encoding a payload, wherein:
- the RNA polynucleotide optionally comprises a modified uridine in place of one or more uridines;
- and
- the 5′ terminus of the RNA polynucleotide comprises m7(3′OMeG)(5′)ppp(5′)(2′OMeA1)pG2pA3pA4pN5, wherein N5 is uridine or a modified uridine.
A composition or medical preparation comprising an RNA polynucleotide comprising a sequence encoding a payload, wherein:
- the RNA polynucleotide optionally comprises a modified uridine in place of one or more uridines;
- and
- the 5′ terminus of the RNA polynucleotide comprises m7(3′OMeG)(5′)ppp(5′)(2′OMeA1)pG2pA3pN4pN5, wherein N4 and N5 are each independently selected from A, G, C, U, or a modified uridine.
A pharmaceutical composition comprising an RNA polynucleotide formulated as a particle, wherein the RNA polynucleotide comprises a sequence encoding a payload, wherein:
- the RNA polynucleotide optionally comprises a modified uridine in place of one or more uridines;
- and
- the 5′ terminus of the RNA polynucleotide comprises m7(3′OMeG)(5′)ppp(5′)(2′OMeA1)pG2pA3pN4pN5, wherein N4 and Ns are each independently selected from A, G, C, U, or a modified uridine.
Dependencies are inferred from the claim text.