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US 11,951,177 B2Granted
High sterol-containing lipid nanoparticles
AssigneeNanoVation Therapeutics Inc.
InventorsKevin An, Daniel Kurek, Jayesh Kulkarni, Dominik Witzigmann
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Abstract
The present disclosure provides a lipid nanoparticle comprising: a nucleic acid cargo molecule; sterol or a derivative thereof present at elevated content; neutral lipid; an ionizable lipid; and a hydrophilic polymer-lipid conjugate present at a content between 0.5 and 3 mol %, wherein each mol % content is relative to total lipid present in the lipid nanoparticle.
Claims16
A lipid nanoparticle comprising:
- a nucleic acid cargo molecule;
- a sterol or a derivative thereof present at a mol % content between 49 mol % and 85 mol %;
- a phospholipid content of 4 mol % or less;
- an ionizable lipid content that is less than 40 mol %;
- and
- a hydrophilic polymer-lipid conjugate present at a content between 0.5 and 2.5 mol %,
- wherein each mol % content is relative to total lipid present in the lipid nanoparticle.
4 more elements
Dependencies are inferred from the claim text.