US 11,951,170 B2 · Chemically coupled transporter for low-hydrophobicity bioactive drugs into the central nervous system

Chemically coupled transporter for low-hydrophobicity bioactive drugs into the central nervous system

AssigneesSkybio LLC, Consejo Nacional de Investigaciones Cientificas y Ténicas (Conicet), Universidad Nacional De Tucuman, Universidad De Buenos Aires, Sistema Provincial De Salud De Tucumán

InventorsOscar José Varela, Rosana Nieves Chehín, Cesar Luis Ávila, Sergio Benjamin Socías, Diego Ploper, Esteban Vera Pingitore, Analía Silvina Chaves, Martin Luong, Verónica Elena Manzano, Rodrigo Hernán Tomas Grau, Maria Florencia González Lizárraga, Adriana Andrea Kolender, Agustín Osvaldo Pernicone

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Abstract

The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, wherein the modified tetracycline derivative is optionally defined by the following formula:

Claims2

Dependent claims

A compound comprising a modified tetracycline derivative, covalently coupled through a linker to dopamine, wherein the compound is defined by the following formula:

Dependencies are inferred from the claim text.