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US 11,951,169 B2Granted
Pharmaceutical preparation with curcuminoids nanoparticles and a method for producing the same
AssigneeAastar Pte Ltd.
InventorThe Huy Tran
Life of this patent
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Abstract
The present disclosure relates to a pharmaceutical composition having a mixture containing curcuminoids as at least one of the active therapeutic agents. Generally, the mixture comprises 4-8% by weight of purified curcuminoids; 20-35% by weight of an oil phase; 25-35% by weight of a co-solvent; and 40-50% by weight of a surfactant. Preferably, the purified curcuminoids in the mixture has an average size of about 19 nm or at least half of the curcuminoids carried in the mixture has particle size not exceeding 19 nm.
Claims12
A pharmaceutical composition having a mixture comprising:
- 4-8% by weight of purified curcuminoids;
- 20-35% by weight of an oil phase;
- 25-35% by weight of a co-solvent;
- and
- 40-50% by weight of a surfactant,
- wherein the purified curcuminoids are acquired by dissolving a polar extract of turmeric powder with a solvent mixture comprising paraffin and iso-propanol followed by filtration to generate a filtrate and crystallization of the filtrate to produce crystal having the purified curcuminoids then drying the crystal to obtain standardization 95% purified curcuminoids,
- wherein the purified curcuminoids in the mixture has an average size of about 19 nm,
- wherein the purified curcuminoids comprises curcumin I, curcumin II and curcumin III in a weight ratio of 80 to 85:10 to 15:1 to 5.
5 more elements
A method of producing a pharmaceutical composition comprising:
- providing dried pulverized powder of turmeric;
- reacting the powder with an organic polar extraction solvent using percolation extraction;
- acquiring a polar extract of the powder from the reacted extraction solvent;
- purifying the polar extract to obtain purified curcuminoids;
- mixing the purified curcuminoids with an oil phase, a co-solvent, and a surfactant in a weight ratio of 4-8:20-35:20-35:40-50 to produce the pharmaceutical composition, wherein the purified curcuminoids in the produced pharmaceutical composition has an average size of about 19 nm, wherein the purifying comprises dissolving the polar extract with a solvent mixture comprising paraffin and iso-propanol followed by filtration to generate a filtrate and crystallization of the filtrate to produce crystal having the purified curcuminoids then drying the crystal to obtain standardization 95% purified curcuminoids, wherein the purified curcuminoids comprises curcumin I, curcumin II and curcumin III in a weight ratio of 80 to 85:10 to 15:1 to 5.
2 more elements
Dependencies are inferred from the claim text.