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US 11,951,161 B2Granted
Methods for inducing an immune response
AssigneeGlaxosmithkline Biologicals SA
InventorsWilliam Ripley Ballou, Jr., Arnaud Michel Didierlaurent, Robbert Gerrit Van Der Most
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Abstract
Methods of inducing an immune response comprising at least two administrations of an adjuvanted immunogenic composition, wherein the second administration contains reduced amounts of antigen and adjuvant.
Claims17
A method for inducing an immune response in a human subject comprising administering to the subject:
- (a) a first immunogenic composition comprising one or more antigens and a first adjuvant, and
- (b) a second immunogenic composition comprising one or more antigens and a second adjuvant,
- wherein:
- (i) the time interval between administration of the first immunogenic composition and the second immunogenic composition is between 1 and 24 months,
- (ii) the first and second immunogenic compositions have at least one antigen in common, the common antigen is a Plasmodium antigen, and the second immunogenic composition contains between 2-50 fold lower amount of said common antigen than the first composition, and
- (iii) the first and second adjuvants comprise 3D-MPL and QS21 in a liposomal formulation in the same relative proportions, and the second immunogenic composition contains between 2-50 fold lower amount of said liposomal adjuvant than the first immunogenic composition.
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Dependencies are inferred from the claim text.