Compositions and methods for administering PPARγ agonists, surfactant peptides and phospholipids

A method of preventing or treating surfactant deficiency or dysfunction in a patient in need thereof, comprising aerosol administration of composition comprising:

• a PPAR (peroxisome proliferator-activated receptor) gamma agonist;
• one or more surfactant peptides;
• and
• one or more phospholipids,
• wherein the patient is an infant wherein at least one of the one or more surfactant peptides comprises:
• (i) a first fragment comprising the amino acid sequence of XWLXRALIKRIQAZI (SEQ ID NO:
• 1) or a first amino acid sequence having at least 90% sequence identity to SEQ ID NO:
• 1 and
• (ii) a second fragment comprising the amino acid sequence of RZLPQLVXRLVLRXS (SEQ ID NO:
• 2) or a second amino acid sequence having at least 90% sequence identity to SEQ ID NO:
• 2,
• wherein (a) X is any amino acid but at least one amino acid at the X positions is tyrosine, and (b) Z is any amino acid but not methionine.