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AssigneesThe Brigham and Women's Hospital, Inc., Acceleron Pharma Inc.
InventorsPaul B. Yu, Asya Grinberg, Dianne S. Sako, Roselyne Castonguay, Rita Steeves, Ravindra Kumar
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In some aspects, the invention teaches pharmaceutical compositions that include a TGF-β ligand trap, and methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-β ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-β signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-β ligand trap to reduce right ventricular systolic pressure in a subject.
A method of treating, preventing, or reducing the progression rate of pulmonary hypertension (PH) in a subject, comprising administering to a subject in need thereof a polypeptide comprising a transforming growth factor-β (TGF-β) ligand binding domain of a TGF-β type II receptor and an Fc domain of an immunoglobulin, wherein the TGF-β ligand binding domain comprises the amino acid sequence as set forth in SEQ ID NO:
A method of treating, preventing, or reducing the progression rate of pulmonary vascular remodeling, pulmonary fibrosis, or right ventricular hypertrophy in a subject that has pulmonary hypertension (PH), comprising administering to a subject in need thereof a polypeptide comprising a transforming growth factor-β (TGF-β) ligand binding domain of a TGF-β type II receptor and an Fc domain of an immunoglobulin, wherein the TGF-β ligand binding domain comprises the amino acid sequence as set forth in SEQ ID NO:
A method of reducing right ventricular systolic pressure in a subject that has pulmonary hypertension (PH), comprising administering to a subject in need thereof a polypeptide comprising a transforming growth factor-β (TGF-β) ligand binding domain of a TGF-β type II receptor and an Fc domain of an immunoglobulin, wherein the TGF-β ligand binding domain comprises the amino acid sequence as set forth in SEQ ID NO:
Dependencies are inferred from the claim text.