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US 11,951,152 B1Granted
Microparticle compositions for controlled delivery of telmisartan and actinomycin D
AssigneesUniversity of South Florida, The United States Government AS Represented By the Department of Veteran Affairs
InventorsSubhra Mohapatra, Shyam S. Mohapatra, Eleni Markoutsa, Alejandro J. Gonzalez, Heta N. Jadhav
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Abstract
This disclosure is directed to therapeutic compositions, and more particularly to microparticle compositions for the controlled delivery of telmisartan and actinomycin D.
Claims18
A therapeutic composition comprising:
- a plurality of liposomal microparticles;
- a plurality of terephthalaldehyde (TPA)-crosslinked chitosan nanoparticles encapsulated within the liposomal microparticles, wherein the TPA-crosslinked chitosan nanoparticles are loaded with actinomycin D;
- and
- a plurality of tripolyphosphate (TPP)-crosslinked chitosan nanoparticles encapsulated within the liposomal microparticles, wherein the TPP-crosslinked chitosan nanoparticles are loaded with telmisartan.
1 more element
Dependencies are inferred from the claim text.