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US 11,951,141 B2Granted
Replication-enhanced oncolytic adenoviruses
AssigneesMEMGen Corporation, H. Lee Moffitt Cancer Center and Research Institute, Inc.
InventorsMark J. Cantwell, Amer A. Beg
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Abstract
Disclosed are replication-enhanced oncolytic adenoviruses. These oncolytic adenoviruses have tumor-specific replication capable of enhanced tumor oncolysis and enhanced therapeutic transgene expression. Also disclosed are methods comprising administering a replication-enhanced oncolytic adenovirus for patients suffering from a cancer.
Claims7
An adenovirus vector, wherein the adenovirus vector comprises:
- a. a CMV promoter/enhancer inserted in a noncoding region upstream of the adenovirus E1 coding region;
- b. a SV40 promoter/enhancer inserted in the adenovirus E3 region;
- c. a deletion in part or all of the E3 coding region;
- d. a E1A gene comprising a delta-24 deletion;
- e. a E1B 55K deletion;
- f. wherein the CMV promoter/enhancer is operably linked to a heterologous nucleic acid sequence encoding MEM40;
- and
- g. wherein the SV40 promoter/enhancer is operably linked to a heterologous nucleic acid sequence encoding IFNβ.
5 more elements
Dependencies are inferred from the claim text.