Preservation of pancreatic islet grafts in the extrahepatic space
AssigneesThe Regents of the University of California, The United States Government as represented by the Department of Veterans Affairs
InventorsCasey Ward, Qizhi Tang, Peter Stock, Gaetano Faleo, Gopika Nair, Matthias Hebrok, Wenhan Chang, Thuy Vo, Jeffrey A. Bluestone, Eleonora De Klerk
Life of this patent
Estimating the term…
Abstract
Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.
Claims24
A method for treating diabetes mellitus in an individual in need thereof, comprising administering to the individual a transplant comprising:
- (a) an insulin-producing cell, and
- (b) a cell selected from (i) a cell derived from a parathyroid gland (PTG) and (ii) a CD34+ cell, wherein the cell produces one or more factors selected from a proangiogenic factor, a PTG hormone, and a combination thereof,
- thereby treating the diabetes mellitus.
A method for treating diabetes mellitus in an individual in need thereof, comprising administering to the individual a transplant comprising:
- (a) an insulin-producing cell,
- (b) a cell that produces one or more PTG hormones;
- and
- (c) a cell that produces one or more proangiogenic factors, thereby treating the diabetes mellitus.
Dependencies are inferred from the claim text.