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US 11,951,131 B2Granted
Anti-SLAMF7 chimeric antigen receptors
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsJames N. Kochenderfer, Steven A. Feldman
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Abstract
Provided are chimeric antigen receptors (CARs) having antigenic specificity for B-cell Maturation Antigen (SLAMF7). Also provided are related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs. Methods of treating or preventing cancer in a mammal are also provided.
Claims16
A nucleic acid comprising:
- (a) a suicide gene;
- and
- (b) a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises a single chain comprising an antigen recognition domain, a transmembrane (TM) domain, and a T cell activation domain, wherein the CAR has antigenic specificity for signaling lymphocyte activating molecule F7 (SLAMF7), wherein the TM domain comprises a TM domain of CD8α or CD28, wherein the antigen recognition domain comprises the amino acid sequences of SEQ ID NOs:
- 1-6;
- wherein the nucleotide sequence encoding the CAR is positioned 3′ of the suicide gene, and wherein the suicide gene is an inducible caspase 9 (IC9) gene.
2 more elements
A nucleic acid comprising:
- (a) a suicide gene;
- and
- (b) a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises a single chain comprising, from the N-terminus to the C-terminus:
- a CD8α signal sequence, an antigen recognition domain, a human CD8 α hinge and transmembrane domain, a cytoplasmic portion of human CD28, and a cytoplasmic portion of human CD3ζ,
- wherein the CAR has antigenic specificity for signaling lymphocyte activating molecule F7 (SLAM F7),
- wherein the antigen recognition domain comprises the amino acid sequences of SEQ ID NOs:
- 1-6;
- wherein the nucleotide sequence encoding the CAR is positioned 3′ of the suicide gene, and wherein the suicide gene is an inducible caspase 9 (IC9) gene.
5 more elements
Dependencies are inferred from the claim text.