Compositions and methods for the isolation and/or generation of specific CD4+ and CD8+ T-cell subsets
AssigneeLa Jolla Institute for Allergy and Immunology
InventorsHilde Cheroutre, Nicolas Thiault, Alexandre Larange, Hitoshi Iwaya
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Abstract
The present disclosure relates to particular subsets of CD4+ and CD8+ T-cells, methods of isolating and generating these cells, compositions comprising these cells, and methods of treatment of a tumor or cancer by administering these cells alone or in combination with each other and/or additional therapies.
Claims8
A method of generating a population of tumor-specific CD4+ cytotoxic T-cells comprising contacting a population of tumor-specific CD4+ T-cells with an effective amount of a combination comprising cytokines and retinoic acid thereby generating tumor-specific CD4+ cytotoxic T-cells, and wherein the cytokines consist of TGF-β, and IL-27.
A method of generating a population of tumor-specific CD4+ cytotoxic T-cells comprising contacting a population of tumor-specific CD4+ T-cells with an effective amount of a combination consisting of retinoic acid, TGF-β, IL-27 and an effective amount of an anti-CD3 or an anti-CD28 antibody thereby generating tumor-specific CD4+ cytotoxic T-cells.
Dependencies are inferred from the claim text.