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US 11,951,120 B2Granted
Modification of gene transcription and translation efficiency by 5′UTR sequence variation
AssigneeNanjing GeneLeap Biotechnology Co., Ltd.
InventorsJaewoo Lee, Dehua Wang, Xiaoyao Hao, Yue Gao, Jie Liu, Shan He, Ting He, Dan Tse
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Abstract
This invention relates to the fields of mRNA vaccines, mRNA therapy, and gene therapy and specifically to the use of gene expression vectors or PCR amplicons containing various 5′UTR sequences followed by coding sequences for in vitro and in vivo production of mRNA or proteins of interest.
Claims20
An isolated nucleic acid comprising, in the 5′ to 3′ direction:
- a) at least one 5′UTR element, said 5′UTR element comprising polynucleotides comprising SEQ ID NO:
- 38;
- and
- b) at least one open reading frame (ORF) encoding a peptide or protein.
1 more element
An mRNA comprising, in the 5′ to 3′ direction:
- a) at least one 5′UTR element, said 5′UTR element comprising polynucleotides comprising SEQ ID NO:
- 38;
- and
- b) at least one open reading frame (ORF) encoding a peptide or protein.
1 more element
Dependencies are inferred from the claim text.