Synergestic combination composition comprising a steroidal saponin, a first polyphenolic compound and a second polyphenolic compound
AssigneeNeuralia
InventorNoëlle Callizot
Life of this patent
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Abstract
A combination composition including as active components, in synergistically effective amounts of (i) a steroidal saponin of natural or synthetic origin, a pharmaceutical acceptable salt thereof or a plant extract containing steroidal saponin, and (ii) at least a first polyphenolic compound selected from the group of hydroxycinnamic acids, flavonoids, hydroxybenzoic acids, and (iii) optionally, a second polyphenolic compound, wherein the second polyphenolic compound is hydroxycinnamic acids and its use in preventing, inhibiting, retarding or treating a subject suffering from a neurodegenerative disease or condition.
Claims11
A combination composition comprising as active components:
- a steroidal saponin of natural or synthetic origin, a pharmaceutical acceptable salt thereof, at a concentration of 0.03 pM to 0.3 pM;
- caffeic acid as first polyphenolic compound at a concentration of 5 nM to 50 nM;
- and
- ferulic acid as second polyphenolic compound at a concentration of 1 nM to 10 nM,
- wherein the active components of the combination composition consist of the steroidal saponin of natural or synthetic origin, a pharmaceutical acceptable salt thereof, caffeic acid and ferulic acid,
- wherein the steroidal saponin is selected from the group consisting of diosgenin, dioscin, protodioscin, sarsasapogenin, sarsaponin, smilagenin, tigogenin, laxogenin, and mixtures thereof, and
- wherein said concentration of 0.03 pM to 0.3 pM of steroidal saponin is an effective concentration less than an effective concentration of steroidal saponin required without caffeic acid at said concentration of 5 nM to 50 nM and/or ferulic acid at said concentration of 1 nM to 10 nM.
Dependencies are inferred from the claim text.