Aripiprazole sustained-release microsphere and preparation method therefor

An aripiprazole sustained-release microsphere, comprising aripiprazole or salts thereof and poly(lactide-co-glycolide) copolymer;

• wherein,
• the microsphere is in a spherical reticulate skeleton structure, small reticular holes are distributed in the sphere;
• and the aripiprazole or salts thereof are filled in the holes;
• the microsphere has a mean particle size of less than 20 μm;
• the aripiprazole or salts thereof has a content of 71%-80% of a total weight of the microsphere;
• wherein, the poly(lactide-co-glycolide) copolymer has an intrinsic viscosity of 0.2-0.55 dL/g;
• a polydispersity index of 1.0-3.0;
• and a weight-average molecular weight of 15000-60000;
• and
• a molar ratio of lactide to glycolide in the poly(lactide-co-glycolide) copolymer is 50:50-65:35.