Non-hormonal compositions and methods for male contraception

A method for reversible, continuous non-hormonal contraception in a male subject, the method comprising administering once daily at about the same time, a dose of a composition comprising:

• (i) an extended release formulation of (R)-silodosin in an amount of about 4 mg to about 30 mg, the amount effective, when administered once daily at about the same time, to induce a reversible condition of aspermia, azoospermia or severe oligozoospermia sufficient for contraceptive effect in the male subject;
• and
• (ii) a pharmaceutically acceptable carrier,
• wherein a delay in administering one daily dose after an initial period of at least two consecutive days with doses administered at about the same time does not affect the contraceptive effect in the male subject, wherein the delay does not exceed 2, 4, 6, 8, 10 12, 16, 20 or 24 hours from the day-before intake time.

A method for reversible, continuous non-hormonal contraception in a male subject, the method comprising administering once daily at about the same time, a dose of a composition comprising:

• (i) an extended release formulation of (R)-silodosin in an amount of about 4 mg to about 30 mg, the amount effective, when administered once daily at about the same time, to induce a reversible condition of aspermia, azoospermia or severe oligozoospermia sufficient for contraceptive effect in the male subject;
• and
• (ii) a pharmaceutically acceptable carrier,
• wherein once daily administration of the formulation at about the same time provides a reversible contraceptive effect, but does not cause discomfort upon ejaculation in the male subject.