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US 11,951,083 B2Granted
Methods of manufacturing 14,15-epoxyeicosatrienoic acid analogs and improved therapeutic delivery of same
AssigneeCytometix, Inc.
InventorsJohn R. Falck, Lane Brostrom
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Abstract
Systems, compositions, and methods are disclosed for developing and delivering therapeutically effective 14,15-epoxyeicosatrienoic acid (14,15-EET) analogs, for example for pain management or treatment. Of particular interest are intermediate salts.
Claims24
A method of providing a first intermediate salt, comprising the steps of:
- and
- using one of a metallic base or a first amine base with compound 2 to form the first intermediate salt;
- and
- purifying the first intermediate salt by crystallization,
- wherein A1 applies a first acid, and R1 is a hydroxyl group, and the first intermediate salt is crystalline.
2 more elements
A composition comprising a salt of compound 2:
- wherein R1 is a hydroxyl group and the salt is selected from the group consisting of a metal salt and an amine salt, and wherein the salt is crystalline.
A composition comprising a salt of compound 4:
- wherein R2 is selected from the group consisting of a C3-C6 cycloalkyl substituted amine, a C5-C6 cycloalkenyl substituted amine (excluding enamines), and ester, and wherein the salt is an acid salt, wherein the salt is crystalline.
Dependencies are inferred from the claim text.