Systems and methods for delivering biomaterials
AssigneeContraline, Inc.
InventorsGregory Grover, Kevin S. Eisenfrats
Life of this patent
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Abstract
Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.
Claims19
A method of delivering a composition, comprising:
- coupling a container assembly to a delivery device, the container assembly including a first component and a second component separate from the first component, the delivery device including a drive assembly;
- inserting a first delivery member into a first body lumen;
- coupling, after the inserting the first delivery member, the first delivery member to the container assembly;
- actuating the delivery device to cause the drive assembly to produce a first drive force to convey a first portion of the first component and a first portion of the second component from the container assembly and through the first delivery member, the first component crosslinking with the second component to form a first hydrogel within the first delivery member, the first hydrogel being conveyed into the first body lumen, the first body lumen being a first vas deferens of a patient;
- decoupling, after the actuating, the first delivery member from the container assembly;
- inserting a second delivery member into a second body lumen, the second body lumen being a second vas deferens of the patient;
- coupling, after the inserting the second delivery member, the second delivery member to the container assembly;
- and
- actuating the delivery device to cause the drive assembly to produce a second drive force to convey a second portion of the first component and a second portion of the second component from the container assembly and through the second delivery member, the first component crosslinking with the second component to form a second hydrogel within the second delivery member, the second hydrogel being conveyed into the second body lumen.
A method of delivering a composition to a body lumen within a body, comprising:
- inserting an outlet portion of a delivery member into the body lumen, a coupling portion of the delivery member being outside of the body;
- coupling, after the inserting, a container assembly to the coupling portion of the delivery member, the container assembly including a first component and a second component, the coupling being performed such that a bolus of air is retained within at least a portion of the delivery member;
- conveying the first component and the second component into the delivery member, the first component crosslinking with the second component to form a hydrogel within the delivery member, the conveying the first component and the second component into the delivery member causing the bolus of air to be delivered into the body lumen via the outlet portion of the delivery member;
- and
- conveying, after the conveying the first component and the second component into the delivery member, the hydrogel into the body lumen via the outlet portion of the delivery member.
Dependencies are inferred from the claim text.