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US 11,950,792 B2Granted
Intravascular ultrasound device and methods for avoiding or treating reperfusion injury
AssigneesUniversity of Cincinnati, Children's Hospital Medical Center
InventorsKevin Haworth, Christy K. Holland, Karla Mercado-Shekhar, Andrew Redington, Bryan H. Goldstein
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Abstract
An intravascular ultrasound (IVUS) catheter-based device for targeted delivery of ultrasound-activated emulsions of oxygen-scavenging droplets into a bloodstream of patients suffering from a hypoxic condition and methods utilizing the device to protect the patients from reperfusion injury upon restoration of oxygenated blood to a hypoxic tissue.
Claims18
A method for protecting a patient suffering from a hypoxic condition against reperfusion injury, the method comprising:
- inserting a catheter of a catheter-based system into a target blood vessel of the patient;
- delivering a perfluorocarbon emulsion into the catheter of the catheter-based system;
- activating the perfluorocarbon emulsion within the catheter of the catheter-based system by application of intra-vascular ultrasound;
- and delivering the activated perfluorocarbon emulsion to the target blood vessel of the patient to allow the activated perfluorocarbon emulsion to scavenge dissolved oxygen present in blood flowing in the target blood vessel.
1 more element
Dependencies are inferred from the claim text.