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US 11,950,590 B2Granted
Methods to improve organ viability
AssigneeMallinckrodt Pharmaceuticals Ireland Limited
InventorJim Potenziano
Life of this patent
Estimating the term…
Abstract
The present disclosure provides methods to improve the viability of an organ, or organs, by continuously administering a composition comprising NOx gas directly to the organ(s).
Claims13
A method to improve the viability of an organ intended for transplant or damaged by ischemia-reperfusion, the method comprising:
- administering to the organ an initial dose of about 0.05 ppm to about 20 ppm of nitric oxide (NO) gas directly to the organ via an organ perfusion system or ventilation;
- and
- incrementally increasing the dose of NO gas by increments of 0.1 ppm to 5 ppm until the viability of the organ is increased, the dose of NO gas exceeds 50 ppm, or a methemoglobin level exceeds 5%.
A method to improve the viability of an organ intended for transplant or damaged by ischemia-reperfusion, the method comprising:
- administering to the organ an initial dose of about 0.05 ppm to about 20 ppm of nitric oxide (NO) gas directly to the organ via an organ perfusion system or ventilation;
- and
- adjusting the dose of NO gas until the viability of the organ is increased, the dose of NO gas exceeds 50 ppm, or a methemoglobin level exceeds 5%.
Dependencies are inferred from the claim text.