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US 11,946,838 B2Granted
Calibration slides for digital pathology
AssigneeVentana Medical Systems, Inc.
InventorChristian Roessler
Life of this patent
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Abstract
In some embodiments, the present disclosure is directed to coatings or thin films comprising a dye or stain embedded within a matrix, e.g. a polymer matrix.
Claims20
A calibration system comprising:
- (a) an optically transparent substrate;
- (b) a film having a substantially uniform thickness disposed on at least a portion of the optically transparent substrate, the film comprising a chromogenic precipitate embedded within a polymer, wherein the chromogenic precipitate is uniformly dispersed within the polymer.
A set of slides comprising:
- (a) a first slide having a first coating disposed on at least a portion of an upper surface of the first slide, the first coating comprising a stain present in a polymeric matrix at a first concentration;
- (b) a second slide having a second coating disposed on at least a portion of an upper surface of the second slide, the second coating comprising the stain present in the polymeric matrix at a second concentration;
- wherein the first concentration and the second concentration are different.
A kit comprising:
- (i) a first set of coating reagents comprising:
- a. a first intermediate coating solution comprising a first matrix forming component and an enzyme;
- and
- b. a second intermediate coating solution comprising a chromogen, wherein the chromogen is present in the second intermediate coating solution at a first concentration;
- and
- (ii) a second set of coating reagents comprising
- a. a third intermediate coating solution comprising the first matrix forming component and the enzyme;
- and
- b. a fourth intermediate coating solution comprising the chromogen, wherein the chromogen is present in the fourth intermediate coating solution at a second concentration.
6 more elements
Dependencies are inferred from the claim text.