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AssigneesFraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Angewandten Forschung E.V.
InventorsThomas Grunwald, Lea Bayer
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A non-human papilloma pseudovirus or virus like particle has at least one papilloma capsid protein codon-optimized for expression in eukaryotic cells or cell lines. A pharmaceutical composition includes the non-human papilloma pseudovirus or virus like particle, and a diagnostic agent, an imaging agent, and a therapeutic agent. A non-human papilloma pseudovirus or virus like particle can be used as a medicament. A method for producing a non-human papilloma pseudovirus or virus like particle involves codon-optimizing of capsid proteins of non-human papillomaviruses for expression in eukaryotic cells, synthesizing of the sequences and cloning of the synthesized sequences into expression vectors, and producing non-human papilloma pseudovirus or virus like particles. ι-carrageenan can be used as transduction enhancer for non-human papilloma pseudovirus or virus like particles in vitro.
A non-human papilloma pseudovirus or virus-like particle comprising at least one codon-optimized nucleic acid sequence encoding a papilloma capsid protein for expression in eukaryotic cells or cell lines, wherein the codon-optimized nucleic acid sequence is as shown in SEQ ID NOS. 1 to 20.
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