Headless hemagglutin influenza vaccine
AssigneeGerogia State University Research Foundation, Inc.
InventorsBaozhong Wang, Lei Deng
Life of this patent
Estimating the term…
Abstract
Disclosed are universal influenza based on a truncated influenza hemagglutin (HA) protein lacking a head domain (hrHA). Also disclosed is a composition comprising a nanoparticle coated with a disclosed hrHA polypeptide. Also disclosed is a composition comprising a virus like particle (VLP) expressing on its surface a disclosed hrHA polypeptide.
Claims12
A nanoparticle formed by crosslinking a fusion protein with a crosslinking agent and/or desolvating the fusion protein with a desolvating agent, wherein the fusion protein comprises a series of 2 to 8 influenza virus matrix protein 2 extracellular (M2e) domains, wherein the series of 2 to 8 influenza virus M2e domains is linked to a multimerization domain, wherein the fusion protein further comprises influenza neuraminidase (NA) protein linked to the multimerization domain.
Dependencies are inferred from the claim text.