Targeting RNA viruses using inhibitors of METTL3
AssigneeNew York University
InventorsIan Mohr, Hannah Burgess, Angus Wilson
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Abstract
Provided are methods for prophylaxis or therapy for an RNA virus infection. The methods involve modulating the Type I interferon pathway in RNA virus infected cells of an individual. The Type I interferon pathway is modulated by administering one or more agents to virus infected cells that inhibit the expression and/or function of METTL3 or inhibit expression and/or function of YTHDF1, YTHDF2 or YTHDF3.
Claims10
A method for prophylaxis or therapy for an RNA virus infection, the method comprising modulating the Type I interferon pathway in RNA virus infected cells of the individual by administering one or more agents to the individual that inhibit function of METTL3, wherein the one or more agents are selected from the group consisting of
- and a combination thereof.
A method comprising delivering to RNA virus infected cells one or more agents that inhibit function of METTL3, wherein the one or more agents are selected from the group consisting of:
- and a combination thereof.
Dependencies are inferred from the claim text.