Compositions for application to wounds

A method of forming a composition for application to a wound, the method comprising:

• providing a first layer comprising a skin adhesive with a low water absorption, such that, when immersed in water at 20° C. for a period of 1 hour, the skin adhesive absorbs an amount of water equal to 40% or less of a weight of the skin adhesive,
• wherein the first layer has a wound-facing side and a non-wound-facing side and, in a first area, apertures extend through the first layer from the wound-facing side to the non-wound-facing side, the first layer having a second area that extends to an edge of the composition and forms a perimeter around the first area, the perimeter lacking apertures therethrough,
• wherein a mean area of the apertures on at least one of the wound-facing side and non-wound-facing side of the first layer is at least 20 mm2,
• the first layer being disposed on a third layer that comprises a polymeric film, the third layer being a supporting layer for the first layer and having apertures therethrough substantially corresponding to the apertures of the first layer,
• associating a second layer and a fourth layer with the first and third layers, such that the third layer is disposed between the first and second layers and the fourth layer is disposed between the second and third layers, the second layer being an outermost layer of the composition, and, in-use, the wound facing side of the first layer is configured to contact the wound, the second layer comprising a polymeric film that is continuous in that it extends over and covers each of the apertures of the first layer, the second layer having a moisture vapour transmission rate (MVTR) of at least 500 g/m2/24 hours, measured in accordance with BS EN 13726-2:2002;
• wherein the fourth layer comprises an adhesive that contacts the second layer and the third layer, the fourth layer also having apertures therethrough substantially corresponding to the apertures in the first and third layers, and
• wherein each of the first, second, third, and fourth layers extends to the edge of the composition, the third layer being between the first and second layers at the edge and the fourth layer being between the second and third layers at the edge.

A composition for application to a wound, the composition comprising:

• a first layer comprising a skin adhesive comprising a substance selected from a silicone, a hydrocolloid, a polyurethane, an acrylic polymer, a rubber adhesive, or a hydrogel, the substance having a low water absorption such that, when immersed in water at 20° C. for a period of 1 hour, the substance absorbs an amount of water equal to 40% or less of a weight of the substance,
• wherein the first layer has a wound-facing side and a non-wound-facing side and, in a first area, apertures extend through the first layer from the wound-facing side to the non-wound-facing side, the first layer having a second area that extends to an edge of the composition and forms a perimeter around the first area, the perimeter lacking apertures therethrough, and, in-use, the wound-facing side of the first layer is configured to contact the wound,
• wherein a mean area of the apertures on at least one of the wound-facing side and non-wound-facing side of the first layer is at least 20 mm2;
• and
• a second layer disposed adjacent to the non-wound-facing side of the first layer, the second layer being an outermost layer of the composition, the second layer comprising a polymeric film that is continuous in that it extends over and covers each of the apertures of the first layer, the second layer having a moisture vapour transmission rate (MVTR) of at least 500 g/m2/24 hours, measured in accordance with BS EN 13726-2:2002,
• wherein the composition further comprises a third layer disposed between the first layer and second layer, the third layer comprising a polymeric film and being a supporting layer for the first layer, the third layer having apertures therethrough, substantially corresponding to the apertures in the first layer;
• wherein a fourth layer is disposed between the second layer and the third layer, the fourth layer comprising an adhesive that contacts the second layer and the third layer, the fourth layer also having apertures therethrough substantially corresponding to the apertures in the first and third layers;
• and
• wherein the third layer abuts the first layer and the second layer at the edge of the composition.