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AssigneesUniversity of Georgia Research Foundation, Inc., Emory University
InventorsCharles A. Easley, IV, Anthony W. S. Chan
Estimating the term…
Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.
A method of improving embryo development comprising administering into an oocyte or male gamete, or a fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein and a sperm extract to improve development of the fertilized embryo, or a subsequent embryo resulting from fertilization of the oocyte by the male gamete.
A composition comprising a sperm extract and a compound that increases bioavailability of a TET protein to improve development of a fertilized embryo, or a subsequent embryo resulting from fertilization of an oocyte by a male gamete.
A method of improving embryo development comprising administering into a male gamete or a fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of the fertilized embryo, or a subsequent embryo resulting from fertilization of an oocyte by the male gamete,
Dependencies are inferred from the claim text.