Host bacterium specific nanoparticle
AssigneeNational University Corporation Tokai National Higher Education and Research System
InventorsShoichi Mitsunaka, Hiroki Ando
Life of this patent
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Abstract
An object of the present invention is to provide a recombinant phage having high safety and excellent practicality and usefulness. Provided are a recombinant bacteriophage which is deprived of its proliferative capacity and can infect only once due to the fact that a bacteriophage genome in which a part of a virion constituent gene is deleted is stored in a head, and a method for preparing the same. In addition, provided are a recombinant bacteriophage which is deprived of its proliferative capacity and can infect only once due to the fact that a plasmid having a packaging site and encoding a target gene is stored in a head, and a method for preparing the same.
Claims12
A nanoparticle, consisting of a recombinant bacteriophage that includes a head and a tail, and has an ability to infect but no ability to reinfect a host bacterium, the head having stored therein a bacteriophage genome in which a part of a virion constituent gene is deleted, and
- wherein the part of the virion constituent gene which is deleted is a tail gene.
A nanoparticle, consisting of a recombinant bacteriophage that comprises a head and a tail, and has an ability to infect but no ability to re-infect a host bacterium,
- the head having stored therein a plasmid comprising a bacteriophage genome in which a part of a virion constituent gene is deleted having a packaging site and encoding the target gene, wherein the part of the virion constituent gene which is deleted is a tail gene.
A recombinant bacteriophage comprising a head and a tail, and having an ability to infect but no ability to re-infect a host bacterium,
- the head having stored therein a bacteriophage genome in which a part of a virion constituent gene is deleted.
Dependencies are inferred from the claim text.