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US 11,939,584 B2Granted
Methods and microorganisms for making 2,3-butanediol and derivatives thereof from C1 carbons
AssigneePrecigen, Inc.
InventorsXinhua Zhao, Mark Anton Held, Tina Huynh, Lily Yuin Chao, Na Trinh, Matthias Helmut Schmalisch, Bryan Yeh, James Kealey, Kevin Lee Dietzel
Life of this patent
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Abstract
Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.
Claims15
A vector comprising two or more genes encoding:
- (a) an acetoin reductase comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:
- 9;
- (b) an alpha-acetolactate decarboxylase comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:
- 7;
- and/or (c) an acetolactate synthase comprising an amino acid sequence that is at least 90% identical to any one of SEQ ID NO:
- 1, 3, and 19.
3 more elements
Dependencies are inferred from the claim text.