Anti-tryptase antibodies, compositions thereof, and uses thereof
AssigneeGenentech, Inc.
InventorsXiaocheng Chen, Mark Dennis, Janet Jackman, James T. Koerber, Mason Lu, Henry R. Maun, Kathila Rajapaksa, Saroja Ramanujan, Tracy Staton, Lawren Wu, Tangsheng Yi
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Abstract
The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.
Claims33
A method of treating asthma in a human subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an isolated antibody that binds to human tryptase beta 1, or an antigen-binding fragment thereof, wherein the antibody comprises the following six hypervariable regions (HVRs):
- (a) an HVR-H1 comprising the amino acid sequence of DYGMV (SEQ ID NO:
- 7);
- (b) an HVR-H2 comprising the amino acid sequence of FISSGSSTVYYADTMKG (SEQ ID NO:
- 2);
- (c) an HVR-H3 comprising the amino acid sequence of RNYDDWYFDV (SEQ ID NO:
- 8);
- (d) an HVR-L1 comprising the amino acid sequence of SASSSVTYMY (SEQ ID NO:
- 4);
- (e) an HVR-L2 comprising the amino acid sequence of RTSDLAS (SEQ ID NO:
- 5);
- and
- (f) an HVR-L3 comprising the amino acid sequence of QHYHSYPLT (SEQ ID NO:
- 6).
A method of treating mastocytosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an isolated antibody that binds to human tryptase beta 1, or an antigen-binding fragment thereof, wherein the antibody comprises the following six HVRs:
- (a) an HVR-H1 comprising the amino acid sequence of DYGMV (SEQ ID NO:
- 7);
- (b) an HVR-H2 comprising the amino acid sequence of FISSGSSTVYYADTMKG (SEQ ID NO:
- 2);
- (c) an HVR-H3 comprising the amino acid sequence of RNYDDWYFDV (SEQ ID NO:
- 8);
- (d) an HVR-L1 comprising the amino acid sequence of SASSSVTYMY (SEQ ID NO:
- 4);
- (e) an HVR-L2 comprising the amino acid sequence of RTSDLAS (SEQ ID NO:
- 5);
- and
- (f) an HVR-L3 comprising the amino acid sequence of QHYHSYPLT (SEQ ID NO:
- 6).
Dependencies are inferred from the claim text.