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US 11,939,332 B2Granted
Synthesis of coelenterazine
AssigneeInternational Paper Company
InventorsRajagopala Reddy Duvvuru, Rama Bhatt, Anil Kumar
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Abstract
Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.
Claims9
A method of making coelenterazine, comprising:
- (a) reacting 3-benzylpyrazin-2-amine (25) with N-bromosuccinimide to provide 3-benzyl-5-bromopyrazin-2-amine (2);
- (b) reacting the 3-benzyl-5-bromopyrazin-2-amine (2) in two sequential steps to provide 4-(5-amino-6-benzylpyrazin-2-yl)phenol (7) (coelenteramine);
- and
- (c) coupling the 4-(5-amino-6-benzylpyrazin-2-yl)phenol (7) with silyl-protected 1,1-diethoxy-3-(4-hydroxyphenyl)propan-2-one to provide coelenterazine, or a salt thereof.
1 more element
Dependencies are inferred from the claim text.