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US 11,939,311 B2Granted
Acid-labile surfactants
AssigneePromega Corporation
InventorsJoel Walker, Sergei Saveliev, Zhiyang Zeng, Robert Kargbo, Hui Wang, Sergiy Levin, Valerie Ressler, Jun Zhang, Ce Shi, Harry Tetsuo Uyeda, Jean Osterman, Min Zhou, Prabin Rai, Wenhui Zhou
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Abstract
Provided herein are surfactant compounds that can be used to aid in preparation of protein samples for analysis, for example by mass spectrometry.
Claims20
A compound of formula (I):
- or a salt thereof, wherein:
- A is selected from:
- R1 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, and C1-C12 haloalkyl;
- R2 is selected from C4-C20 alkyl, C4-C20 alkenyl, and C4-C20 haloalkyl;
- each R3 is independently selected from C1-C12 alkyl, C2-C12 alkenyl, and C1-C12 haloalkyl;
- m is 1, 2, or 3;
- Ra and Rb, at each occurrence, are independently selected from hydrogen and C1-C3 alkyl;
- Q is selected from C1-C6-alkylene, and C1-C6-hydroxyalkylene;
- or the group -Q-SO3M has a formula:
- and
- each M is independently selected from hydrogen, an alkali metal cation, and NR4+, wherein each R is independently selected from hydrogen and C1-C12 alkyl.
8 more elements
Dependencies are inferred from the claim text.