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US 11,939,291 B2Granted
GRP94 selective inhibitors and uses thereof
AssigneesUniversity of Kansas, University of South Florida
InventorsSanket Jaiprakash Mishra, Brian S. J. Blagg, Chad Anthony Dickey
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Abstract
The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.
Claims20
A compound according to Formula III
- or a pharmaceutically acceptable salt and/or solvate thereof, wherein
- X21 is N or C—R35;
- X22 is N or C—R36;
- X23 is N or C—R37;
- W2 is C(R40)(R41), O, or S;
- R31 is alkyl, cycloalkyl, aryl, heterocyclyl, or X24—R42;
- R32, R33, R34, R35, R36, R37, R38, R39, R40, and R41 are each independently H, OH, alkyl, alkoxy, aryloxy, heteroaryloxy, amino, halo, trifluoromethyl, or cyano;
- X24 is O, S, or NH;
- R42 is alkyl, cycloalkyl, aryl, or heterocyclyl;
- Z2 is O, S, or NH;
- and
- m is 0 or 1.
9 more elements
Dependencies are inferred from the claim text.