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US 11,938,141 B2Granted
Enzymatic process for obtaining 17 alpha-monoesters of cortexolone and/or its 9,11-dehydroderivatives
AssigneeCassiopea S.P.A.
InventorsMauro Ajani, Luigi Moro
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Abstract
The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and/or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction. Furthermore, the present invention refers to new crystalline forms of cortexolone-17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.
Claims12
A topical composition comprising crystalline cortexolone-17α-propionate in at least two crystalline forms selected from the group consisting of crystalline Form I, crystalline Form II, crystalline Form III, and crystalline Form IV, wherein
- crystalline Form I is characterized by a DRX with at least peaks at about:
- 7.6, 8.4, 17.0, and 20.1 degrees 2theta,
- crystalline Form II is characterized by a DRX with at least peaks at about:
- 10.8, 13.3, 16.5, and 21.9 degrees 2theta,
- crystalline Form III is characterized by a DRX with at least peaks at about:
- 6.2, 12.6, 22.4, and 23.7 degrees 2theta, and
- crystalline Form IV has a DRX with at least peaks at about:
- 4.8, 12.9, and 19.5 degrees 2theta.
5 more elements
Dependencies are inferred from the claim text.