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US 11,938,128 B2Granted
Small molecule BAX inhibitors and uses thereof
AssigneesAlbert Einstein College of Medicine, University of Manitoba
InventorsEvripidis Gavathiotis, Richard N. Kitsis, Thomas P. Garner, Dulguun Amgalan, Lorrie Kirshenbaum, Felix Kopp
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Abstract
Compounds, compositions and method of using these compounds are disclosed for treating a disease or disorder in which it is desirable to inhibit BAX, such as a cardiovascular disease or disorder.
Claims22
A compound having the structure of formula (VII)
- wherein
- A is phenyl;
- B is phenyl;
- R1 and R2 are independently none, C1-C5 alkyl, F, Cl, Br, I, CN, NO2, NR42, OR4, CF3, COOH, COOR4, NHR4, OCR4, SR4, SOR4, or SO2R4;
- X is F, Cl, Br, I, NR42, or OR4;
- wherein the bond between X and the main scaffold is a single bond;
- Q is
- R3 is none, H, C1-C6 alkyl, R4(C═O), or (CH2)pOH;
- R4 is H or C1-C3 alkyl;
- Y is S, or N;
- p is 1-3;
- m is 1 and n is 1;
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.