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US 11,933,785 B2Granted
Methods for detection, staging, and surveillance of colorectal adenomas and carcinomas
AssigneeWisconsin Alumni Research Foundation
InventorsMichael Richard Sussman, Melanie Mae Ivancic, Gregory D Kennedy, William Franklin Dove, Perry Joseph Pickhardt, Mark Reichelderfer
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Abstract
This invention provides minimally invasive methods, reagents, diagnostic and prognostic markers useful for staging, prognosis and surveillance of colorectal cancers, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.
Claims13
A method for treating a colorectal cancer patient in need thereof with a neoadjuvant therapy after identifying the patient as having local or regional colorectal cancer, the method comprising:
- (a) assaying a biosample from the patient for the plurality of protein biomarkers comprising CD44, C-reactive protein, inter-alpha trypsin inhibitor, heavy chain H3vitamin D binding protein;
- and dipeptidyl peptidase 4, wherein the protein biomarkers are present in an individual without cancer at reference levels;
- and
- (b) detecting levels of the plurality of the protein biomarkers in the biosample;
- wherein the colorectal cancer patient is treated with neoadjuvant therapy when the levels of these protein biomarkers from the patient′ biosample is higher than the reference protein biomarker levels from individuals without colorectal cancer.
2 more elements
Dependencies are inferred from the claim text.