Chromatography media and methods for producing them
AssigneePuridify Ltd.
InventorsMarc Hummersone, Benjamin Wallis, Frederic Leroux, William Howard Albert Law
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Abstract
The invention discloses a functionalised chromatography medium, comprising: i) at least one non-woven layer (10) of polymeric nano fibres (20) comprising a plurality of nanofibre-nano fibre fusion points (30); ii) a grafted polymer coating covering the polymeric nanofibres and the nanofibre-nanofibre fusion points; iii) a plurality of ligand groups covalently bound to the grafted polymer coating, wherein the ligand groups are capable of interacting with a target biomolecule.
Claims42
A functionalised chromatography medium, comprising:
- i) at least one non-woven layer of polymeric nanofibres comprising a plurality of nanofibre-nanofibre fusion points;
- ii) a grafted polymer coating covering said polymeric nanofibres and said nanofibre-nanofibre fusion points, wherein the grafted polymer coating comprises polymer molecules which are single-point covalently tethered to said polymeric nanofibres, and wherein the polymer molecules comprise glycidol monomer residues formed from a plurality of compounds of formula
- and
- iii) a plurality of ligand groups covalently bound to said grafted polymer coating, wherein said ligand groups are capable of interacting with a target biomolecule.
A functionalised chromatography medium, comprising:
- i) at least one non-woven layer of polymeric nanofibres comprising a plurality of nanofibre-nanofibre fusion points;
- ii) a plurality of grafted polymer molecules single-point covalently tethered to said polymeric nanofibers, wherein the plurality of grafted polymer molecules are formed from a plurality of compounds of formula
- and
- iii) a plurality of ligand groups covalently bound to said grafted polymer molecules, wherein said ligand groups are capable of interacting with a target biomolecule.
Dependencies are inferred from the claim text.