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US 11,931,416 B2Granted
Immolative cell-penetrating complexes for nucleic acid delivery to the lung
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsTim R. Blake, Paul Wender, Robert M. Waymouth, Ronald Levy, Ole Audun Werner Haabeth, Rebecca McClellan, Adrienne Sallets
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Abstract
There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.
Claims13
A cationic amphipathic polymer of formula:
- wherein n21 is an integer from 10 to 20 and
- z2 is independently an integer from 3-10;
- or
- wherein n22 is an integer from 10 to 35 and
- z2 is independently an integer from 5-20;
- wherein
- R1A is independently hydrogen, —CN, —OH, —NH2, —COOH, —CONH2, -NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, -ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- and each of R201 and R202 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl.
5 more elements
Dependencies are inferred from the claim text.