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US 11,930,837 B2Granted
Antibody-cytokine engrafted proteins and methods of use for immune related disorders
AssigneeNovartis AG
InventorsYaiza Diaz-De-Durana, Michael DiDonato, Christophe Filippi, Shelly Meeusen, Glen Spraggon
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Abstract
The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.
Claims7
A method of expanding Treg cells in a patient in need thereof, comprising administering an antibody cytokine engrafted protein comprising:
- (a) a heavy chain variable region (VH) that comprises a HCDR1 of SEQ ID NO:
- 17, a HCDR2 of SEQ ID NO:
- 18, a HCDR3 of SEQ ID NO:
- 19;
- and
- (b) light chain variable region (VL) that comprises a LCDR1 of SEQ ID NO:
- 30, a LCDR2 of SEQ ID NO:
- 31, and a LCDR3 of SEQ ID NO:
- 32;
- and
- wherein the HDCR1 comprises an Interleukin 2 (IL2) molecule.
8 more elements
Dependencies are inferred from the claim text.