Nutritional composition and infant formula for promoting myelination of the brain
AssigneeSociete des Produits Nestle S.A.
InventorsNora Schneider, Jonas Hauser, Sean Deoni, Tamas Bartfai
Life of this patent
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Abstract
A synthetic nutritional composition comprising a fatty acid derivative for use to promote, support or optimise de novo myelination, in particular the de novo myelination trajectory, and/or brain structure, and/or brain connectivity, and/or intellectual potential and/or cognitive potential and/or learning potential and/or cognitive functioning in a subject, in particular a formula fed subject.
Claims11
A method to promote, support or optimise de novo myelination, in particular the de novo myelination trajectory, and/or brain structure, and/or brain connectivity, and/or intellectual potential and/or cognitive potential and/or learning potential and/or cognitive functioning in a formula fed subject in need thereof, the method comprising administering a synthetic nutritional composition comprising a fatty acid derivative to the formula fed subject, wherein the brain structure refers to the amount and/or spatial distribution of myelinated matter throughout the brain, and/or in specific brain regions, the cognitive function is optimised if the formula fed subject's scores in a standardized neurodevelopmental test are less than one standard deviation different from that of an exclusively breastfed subject of a well-nourished mother, and the fatty acid derivative is selected from the group consisting of a free fatty acid, a monoacylglycerol, a diacylglycerol, a triacylglycerol, a cholesterol ester, and combinations thereof and comprises at least one of docosahexaenoic acid, arachidonic acid, nervonic acid, or stearic acid.
A synthetic nutritional composition comprising a fatty acid derivative, other than a phospholipid, selected from the group consisting of docosahexaenoic acid, arachidonic acid, nervonic acid, stearic acid, and the synthetic nutritional composition further comprising an ingredient selected from the group consisting of a mineral, a vitamin, and a phospholipid, wherein if sphingomyelin is present in the synthetic nutritional composition composition, the sphingomyelin is present in an amount of at least 300 mg/kg;
- if folic acid is present in the synthetic nutritional composition composition, the folic acid is present in amount of at least 100 mcg/kg;
- if vitamin B12 is present in the synthetic nutritional composition composition the vitamin B12 his present in amount of at least 5 mcg/100 g;
- if iron is present in the synthetic nutritional composition composition, the iron is present in an amount of at least 5 mg/100 g;
- if the fatty acid derivative comprises docosahexaenoic acid, the docosahexaenoic acid is present in the synthetic nutritional composition in an amount of 60 to 350 mg/100 g;
- if the fatty acid derivative comprises arachidonic acid, the arachidonic acid is present in the synthetic nutritional composition in an amount of 60 to 350 mg/100 g, and all weights are by dry weight of the synthetic nutritional composition, and
- the synthetic nutritional composition is in a form selected from the group consisting of an infant formula, a growing up milk, a composition for infants that is intended to be added or diluted with human breast milk, and a food stuff intended for consumption by an infant and/or child either alone or in combination with human breast milk.
Dependencies are inferred from the claim text.