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US 11,926,604 B2Granted
Myelination stimulator compounds, and methods of treatment
AssigneeUniversity of Florida Research Foundation, Inc.
InventorScott A. Rivkees
Life of this patent
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Abstract
The invention is directed towards compounds, methods of stimulating myelination, stimulating proliferation of oligodendrocytes (OLs) or stimulating oligodendrocyte precursor cells and methods of treating diseases, disorders or symptoms thereof.
Claims13
A compound of Formula I:
- or pharmaceutically acceptable salt thereof, wherein:
- each R1 is independently H, alkyl substituted with 1-3 independent R4;
- each R2 is independently alkyl substituted with 1-3 independent R4;
- or
- R1 and R2 taken together with the nitrogen atom to which they are attached form a heterocycloalkyl ring having 1, 2, or 3 heteroatoms selected from N, O, and S, wherein the heterocycloalkyl ring may be optionally substituted with 1-3 independent R4;
- each R3 is independently alkyl, alkoxy, amino, halo, C(O)R5, C(O)OR5, SR5, or NR5R6;
- each R4 is independently alkoxy, or aryl optionally substituted with 1-3 independent R7;
- each R5 is independently H, or alkyl;
- each R6 is independently H, or alkyl;
- each R7 is independently alkyl, alkoxy, amino, halo, C(O)R5, C(O)OR5, SR5, S(O)2R5, S(O)2NR5R6, or NR5R6;
- n is 0, 1, 2, 3, or 4;
- and
- m is 1,2, 3, or 4.
10 more elements
Dependencies are inferred from the claim text.