Method for synthesis of 2-methyl-2-hydroxyheptane and 2-methyl 2-alkoxyheptanes
AssigneeP2 Science, Inc.
InventorsPatrick Foley, Yonghua Yang, Yong Tu
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Abstract
The present disclosure pertains to a new synthetic method for the preparation of 2-methyl-2-hydroxyheptane and 2-methyl-2-alkoxyheptanes, which are valuable commodities for use in flavors, fragrances and various personal care products, such as cosmetics.
Claims26
A method of making 2-methyl-2-heptanol or a C1-4 alkyl ether thereof (Compound 1) comprising the steps of:
- (A) reacting 6-methyl-5-hepten-2-one (Compound 3) with a hydrazine compound to form an intermediate hydrazone Compound 3-A;
- (B) base-catalyzed reduction of the hydrazone to form Compound 2:
- and
- (C) reacting the 2-methyl-2-heptene (Compound 2) with water or a C1-4 alcohol in the presence of an acid to form Compound 1:
- wherein R is H or C1-4 alkyl.
A method of making 2-methyl-2-heptene (Compound 2) comprising the steps of (A) reacting 6-methyl-5-hepten-2-one (Compound 3) with a hydrazine compound to form an intermediate hydrazone, followed by (B) base-catalyzed reduction of the hydrazone to form Compound 2.
Dependencies are inferred from the claim text.